Where I would start

Where I would start Perfect Dodge, then Dodge Window, would be my first defensive priorities. So much of this combat depends on staying in control when several things are attacking at once. A bigger perfect-dodge window is useful in almost every fight, rather than only against one enemy type. For movement, I'd go Swing Kick, Quick Zip, then Point Launch Boost. Those upgrades improve the thing you spend an enormous amount of time doing: getting around the city. For combat, Air Marshal is a strong early follow-up because it rewards taking fights off the ground. Then I'd build toward weapon removal in Innovator. Guns and shields can interrupt a perfectly good fight, and removing them gives you more options than trying to punch straight through everything. That's a suggested progression based on what these skills do, not a claim that there's one mandatory build. If you enjoy stealth, take the perch branch sooner. If throwing people around is your thing, build out Web Throw. Eventually you can have all of it.